interview
Michael G. Fitzsimons

Q: How do physicians rationalize drug abuse?

A: They’ve worked with these drugs, so they may feel they have some control. They understand the potency, but they don’t necessarily understand how strongly the drugs will affect them. They don’t have someone standing by, the way a patient under anesthesia does.

“You can replay a disease over and over in a petri dish.”
proto, a prefix of progress, connotes first, novel, experimental. Alone, it conjures an entire world of the new: discoveries, directions, ideas. In taking proto as its name, this magazine stakes its ground on medicine’s leading edge—exploring breakthroughs, dissecting controversies and opening a forum for informed debate.
hed-currentissue hormone replacement therapy

Yes. No. Maybe.

Hormone therapy after menopause may prevent heart attacks and cancer—or cause them. New research could show who benefits.

Konrad Hochedlinger

The Other Stem Cells

Once considered mere substitutes for embryonic cells, re-engineered adult cells are making breakthroughs of their own.

wounded economy, wounded healthcare system

Catching a Chill

Ordinarily resistant to economic ills, health care this time is suffering too. Poor and uninsured patients are most at risk.

chimerism, organ transplants

The Transplant Trick

An experimental protocol fools the immune system into accepting a new organ without debilitating drugs. Could it become routine?

public health posters

Shock Value

Art and message merged in twentieth-century posters, raising the alarm about contagions from TB to AIDS. 

A Mighty Worm

C. elegans, a 959-celled Nobel magnet, helped explain cell suicide and launch genomics, and could now revolutionize drug development.

Elite Controllers, HIV, AIDS, immunity, Karen Pancheau, Joseph O’Brien

The Rare Few

Of every 300 people infected with HIV, one doesn't get AIDS. Understanding this uncanny protection might help science imitate nature.

advances

GOOGLING MAY IMPROVE brain function, scientists at the University of California, Los Angeles, have found. In a study in which 24 healthy adults ages 55 to 76 performed Internet searches, those familiar with the Web showed increased brain activity in areas that control decision-making and complex reasoning, areas not stimulated when the subjects engaged in reading tasks. The brain activity registered two times higher in Web-savvy adults than in those with little Internet experience, suggesting that surfing the Net is a worthwhile exercise for aging minds. The study is to appear in a spring issue of The American Journal of Geriatric Psychiatry.

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hed-ontheblogs

“We recently had a patient in the ICU for more than three months. It was clear that she would never leave the hospital…”
— “RN Geena”

“I cannot get my head around the concept of providing care based on protecting myself from litigation and/or losing my license…”
— “RN John”

“'Do you mean to say that even if my patient needs a walker to get up out of his wheelchair he doesn't qualify?' I asked incredulously of the Medicare representative…”
— “RN Keith”